IL-4 regulates specific Arg-1(+) macrophage sFlt-1-mediated inhibition of angiogenesis.

@article{Wu2015IL4RS,
  title={IL-4 regulates specific Arg-1(+) macrophage sFlt-1-mediated inhibition of angiogenesis.},
  author={Wei-kang Wu and Anastasios Georgiadis and David A. Copland and Sidath E. Liyanage and Ulrich F. O. Luhmann and Scott J. Robbie and Jian Liu and Jiahui Wu and James W B Bainbridge and David W Bates and Robin R Ali and Lindsay B. Nicholson and Andrew D Dick},
  journal={The American journal of pathology},
  year={2015},
  volume={185 8},
  pages={2324-35}
}
One of the main drivers for neovascularization in age-related macular degeneration is activation of innate immunity in the presence of macrophages. Here, we demonstrate that T helper cell type 2 cytokines and, in particular, IL-4 condition human and murine monocyte phenotype toward Arg-1(+), and their subsequent behavior limits angiogenesis by increasing soluble fms-like tyrosine kinase 1 (sFlt-1) gene expression. We document that T helper cell type 2 cytokine-conditioned murine macrophages… CONTINUE READING
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