IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites

@article{Morrot2005IL4RE,
  title={IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites},
  author={Alexandre Morrot and Julius C. R. Hafalla and Ian A. Cockburn and Luzia H. Carvalho and Fidel P. Zavala},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={202},
  pages={551 - 560}
}
IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites. Memory CD8+ T cells lacking the IL-4R are unable to establish a stable population residing in nonlymphoid organs, although they develop normally in lymphoid organs. Because memory cells from nonlymphoid organs disappear shortly after immunization, the protective antiparasitic activity of this T cell response also is… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 44 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

CD8 T cell responses to infectious pathogens

P. Wong, E.G.P. Am
  • Annu. Rev. Immunol
  • 2003
VIEW 1 EXCERPT

Such, and IL-4 RECEPTOR–DEPENDENT MEMORY CD8+ T CELLS

S. M. Kaech, J. T. Tan, E. J. Wherry, C.D.B.T. Konieczny
  • Nat. Immunol
  • 2003
VIEW 2 EXCERPTS