IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function.

@article{Rivas2016IL4PB,
  title={IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function.},
  author={Magali Noval Rivas and O T Burton and Hans C. Oettgen and Talal A Chatila},
  journal={The Journal of allergy and clinical immunology},
  year={2016},
  volume={138 3},
  pages={
          801-811.e9
        }
}
BACKGROUND Food allergy is a major health issue, but its pathogenesis remains obscure. Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation. However their role in food allergy is largely unknown. OBJECTIVE We sought to investigate the role of ILC2s in food allergy. METHODS Food allergy-prone mice with a gain-of-function mutation in the IL-4 receptor α chain (Il4raF709) were orally sensitized with food allergens, and the ILC2 compartment was analyzed. The requirement for ILC2s… CONTINUE READING