IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

@inproceedings{VentoTormo2015IL4OS,
  title={IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation},
  author={Roser Vento-Tormo and Carlos Company and Javier Rodr{\'i}guez-Ubreva and Lorenzo de la Rica and Jos{\'e} Manuel Urquiza and Biola Maria Javierre and Radhakrishnan Sabarinathan and Ana Luque and Manel Esteller and Josep M Aran and Damiana {\'A}lvarez-Errico and Esteban Ballestar},
  booktitle={Genome Biology},
  year={2015}
}
The role of cytokines in establishing specific transcriptional programmes in innate immune cells has long been recognized. However, little is known about how these extracellular factors instruct innate immune cell epigenomes to engage specific differentiation states. Human monocytes differentiate under inflammatory conditions into effector cells with non-redundant functions, such as dendritic cells and macrophages. In this context, interleukin 4 (IL-4) and granulocyte macrophage colony… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 41 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Similar Papers

Loading similar papers…