IL-4 modulation of CD4+CD25+ T regulatory cell-mediated suppression.

@article{Pace2005IL4MO,
  title={IL-4 modulation of CD4+CD25+ T regulatory cell-mediated suppression.},
  author={Luigia Pace and Claudio Pioli and G. Doria},
  journal={Journal of immunology},
  year={2005},
  volume={174 12},
  pages={7645-53}
}
Murine CD4(+)CD25(+) T regulatory (Treg) cells were cocultured with CD4(+)CD25(-) Th cells and APCs or purified B cells and stimulated by anti-CD3 mAb. Replacement of APCs by B cells did not significantly affect the suppression of CD4(+)CD25(-) Th cells. When IL-4 was added to separate cell populations, this cytokine promoted CD4(+)CD25(-) Th and CD4(+)CD25(+) Treg cell proliferation, whereas the suppressive competence of CD4(+)CD25(+) Treg cells was preserved. Conversely, IL-4 added to… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…