IL-4 modulation of CD4+CD25+ T regulatory cell-mediated suppression.

  title={IL-4 modulation of CD4+CD25+ T regulatory cell-mediated suppression.},
  author={Luigia Pace and Claudio Pioli and G. Doria},
  journal={Journal of immunology},
  volume={174 12},
Murine CD4(+)CD25(+) T regulatory (Treg) cells were cocultured with CD4(+)CD25(-) Th cells and APCs or purified B cells and stimulated by anti-CD3 mAb. Replacement of APCs by B cells did not significantly affect the suppression of CD4(+)CD25(-) Th cells. When IL-4 was added to separate cell populations, this cytokine promoted CD4(+)CD25(-) Th and CD4(+)CD25(+) Treg cell proliferation, whereas the suppressive competence of CD4(+)CD25(+) Treg cells was preserved. Conversely, IL-4 added to… CONTINUE READING

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