IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6.

@article{Sehra2008IL4IA,
  title={IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6.},
  author={Sarita Sehra and Heather A. Bruns and Ayele-Nati N. Ahyi and Evelyn T. Nguyen and Nathan W Schmidt and Elizabeth G. Michels and G{\"o}tz-Ulrich von B{\"u}low and Michael Kaplan},
  journal={Journal of immunology},
  year={2008},
  volume={180 5},
  pages={
          3551-9
        }
}
IL-4 is required for the pathogenesis of atopic diseases and immune regulation. Stat6 is critical for IL-4-induced gene expression and Th cell differentiation. Recently, we have generated mice expressing a mutant Stat6 (Stat6VT) under control of the CD2 locus control region that is transcriptionally active independent of IL-4 stimulation. To determine whether active Stat6 in T cells is sufficient to alter immune regulation in vivo, we mated Stat6VT transgenic mice to IL-4-deficient mice… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

THE DEVELOPMENT AND COMMITMENT OF T HELPER SUBSETS

VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED