IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.

@article{Shimizu2008IL4inducedSC,
  title={IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.},
  author={Eisuke Shimizu and Kohichi Kawahara and Makoto Kajizono and Makoto Sawada and Hitoshi Nakayama},
  journal={Journal of immunology},
  year={2008},
  volume={181 9},
  pages={6503-13}
}
A hallmark of immunopathology associated with Alzheimer's disease is the presence of activated microglia (MG) surrounding senile plaque deposition of beta-amyloid (Abeta) peptides. Abeta peptides are believed to be potent activators of MG, which leads to Alzheimer's disease pathology, but the role of MG subtypes in Abeta clearance still remains unclear. In this study, we found that IL-4 treatment of rat primary-type 2 MG enhanced uptake and degradation of oligomeric Abeta(1-42) (o-Abeta(1-42… CONTINUE READING
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