IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6.

@article{Ohmori1996IL4inducedEO,
  title={IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6.},
  author={Yoshihiro Ohmori and Michael Smith and Thomas A Hamilton},
  journal={Journal of immunology},
  year={1996},
  volume={157 5},
  pages={2058-65}
}
IL-4 alone or in cooperation with LPS can induce the expression of the gene encoding the secreted-type IL-1 receptor antagonist (sIL-1ra) in mononuclear phagocytes. To determine the nuclear signaling mechanisms involved in this response, the region flanking the transcription start site of the human sIL-1ra gene was placed upstream of the luciferase reporter gene, and the function of specific sequence elements was analyzed following transient transfection in the macrophage-like cell line RAW264… CONTINUE READING

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