IL-4 down-regulates lipopolysaccharide-induced formyl peptide receptor 2 in murine microglial cells by inhibiting the activation of mitogen-activated protein kinases.

@article{Iribarren2003IL4DL,
  title={IL-4 down-regulates lipopolysaccharide-induced formyl peptide receptor 2 in murine microglial cells by inhibiting the activation of mitogen-activated protein kinases.},
  author={Pablo Iribarren and You-hong Cui and Yingying Le and Guoguang Ying and Xia Zhang and Wanghua Gong and Ji ming Wang},
  journal={Journal of immunology},
  year={2003},
  volume={171 10},
  pages={5482-8}
}
Microglial cells actively participate in proinflammatory responses in the CNS. Upon stimulation with the bacterial LPS, microglial cells express a functional formyl peptide receptor 2 which mediates the chemotactic and activating effects of a variety of polypeptide agonists including amyloid beta (Abeta(1-42)), a critical pathogenic agent in Alzheimer's disease. In the present study, we found that LPS-induced expression and function of formyl peptide receptor 2 in microglial cells was markedly… CONTINUE READING

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