IL-4 attenuates the transcriptional activation of both IFN-alpha and IFN-gamma-induced cellular gene expression in monocytes and monocytic cell lines.

@article{Larner1993IL4AT,
  title={IL-4 attenuates the transcriptional activation of both IFN-alpha and IFN-gamma-induced cellular gene expression in monocytes and monocytic cell lines.},
  author={Andrew C Larner and Emanual F. Petricoin and Yohko Nakagawa and David S. Finbloom},
  journal={Journal of immunology},
  year={1993},
  volume={150 5},
  pages={1944-50}
}
The interaction of IFN-alpha and IFN-gamma with monocytes results in several actions that significantly influence the course of an immune response. Many of these effects are proinflammatory and can contribute to the degree of tissue injury at a site of inflammation. Whereas recent investigations target IL-4 as a T cell product that can antagonize some of the responses induced by IFN, little is known regarding the mechanisms involved. We have taken advantage of two well defined systems: the… CONTINUE READING

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