IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity.

@article{Humbert1996IL4AI,
  title={IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity.},
  author={Marc Humbert and Stephen R. Durham and Sun Ying and Patrick T Kimmitt and Julia Barkans and B A Assoufi and R. G. Pfister and G{\"u}nter Menz and D Robinson and Antony B. Kay and Chris J. Corrigan},
  journal={American journal of respiratory and critical care medicine},
  year={1996},
  volume={154 5},
  pages={1497-504}
}
Intrinsic (nonatopic) asthma is considered to be a distinct pathogenetic variant of asthma since, unlike extrinsic (atopic) asthma, patients with the disease are skin test-negative to common aeroallergens, and have total serum IgE concentrations within the normal range. Nevertheless, the recent demonstration of increased numbers of cells expressing the high-affinity IgE receptor in bronchial biopsies from atopic and nonatopic asthmatic subjects, together with epidemiologic evidence indicating… CONTINUE READING