IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B1 and B2 receptors through a STAT6-dependent mechanism.

@article{Souza2013IL4AI,
  title={IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B1 and B2 receptors through a STAT6-dependent mechanism.},
  author={Pedro P C Souza and Anna Bernhold Brechter and Rosana In{\'a}cio Dos Reis and Carlos Alberto de Souza Costa and Patric S. Lundberg and Ulf H. Lerner},
  journal={British journal of pharmacology},
  year={2013},
  volume={169 2},
  pages={400-12}
}
BACKGROUND AND PURPOSE Bone resorption induced by interleukin-1β (IL-1β) and tumour necrosis factor (TNF-α) is synergistically potentiated by kinins, partially due to enhanced kinin receptor expression. Inflammation-induced bone resorption can be impaired by IL-4 and IL-13. The aim was to investigate if expression of B1 and B2 kinin receptors can be affected by IL-4 and IL-13. EXPERIMENTAL APPROACH We examined effects in a human osteoblastic cell line (MG-63), primary human gingival… CONTINUE READING