IL-4 and IFN-γ mRNA Induction in Human Peripheral Lymphocytes Specific for β-Lactam Antibiotics in Immediate or Delayed Hypersensitivity Reactions

@article{Gaspard2004IL4AI,
  title={IL-4 and IFN-γ mRNA Induction in Human Peripheral Lymphocytes Specific for β-Lactam Antibiotics in Immediate or Delayed Hypersensitivity Reactions},
  author={Isabelle Gaspard and Marie-Th´erese Guinnepain and J´erome Laurent and Nicolas Bachot and Saadia Kerdine and Jacques Bertoglio and Marc Pallardy and Herv´e Lebrec},
  journal={Journal of Clinical Immunology},
  year={2004},
  volume={20},
  pages={107-116}
}
β-Lactam antibiotics elicit CD4+ and CD8+ T-cell-mediated immune responses that play a central role in allergic reactions. However, the involvement of a type 1- (Th1 or Tc1) or a type 2-like (Th2 or Tc2) differentiation in drug allergy remains unclear. We investigated the expression of interleukin 4 (IL-4) and interferon gamma (IFN-γ) mRNA by quantitative reverse transcription and polymerase chain reaction (RT-PCR) in patient-derived peripheral blood lymphocytes following specific in vitro… CONTINUE READING

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