IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo.

@article{LavoieLamoureux2010IL4AE,
  title={IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo.},
  author={Anouk Lavoie-Lamoureux and Kantuta Moran and Guy Beauchamp and Susanne Mauel and Falko Steinbach and Josiane Lefebvre-Lavoie and James Martin and J P Lavoie},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2010},
  volume={299 4},
  pages={L472-82}
}
Neutrophils are potent contributors to the lung pathophysiological changes occurring in allergic airway inflammation, which typically involve T helper type 2 (Th2) cytokine overexpression. We have previously reported that equine pulmonary endothelial cells are activated by the Th2 cytokine IL-4 and express chemotactic factors for neutrophils after stimulation. We have further explored the possible mechanisms linking Th2-driven inflammation and neutrophilia by studying the effects of recombinant… CONTINUE READING

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Functional expression of IL-9 receptor by human L480 THE ROLE OF NEUTROPHILS IN ALLERGIC INFLAMMATION

  • S Abdelilah, K Latifa, +5 authors Q. Hamid
  • AJP-Lung Cell Mol Physiol
  • 2010
Highly Influential
16 Excerpts

Regulation by L481 THE ROLE OF NEUTROPHILS IN ALLERGIC INFLAMMATION

  • H Niiro, T Otsuka, +8 authors Y. Niho
  • AJP-Lung Cell Mol Physiol
  • 2010
2 Excerpts

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