IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaB.

@article{AbuAmer2001IL4AO,
  title={IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaB.},
  author={Yousef Abu-Amer},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={107 11},
  pages={1375-85}
}
IL-4, an anti-inflammatory cytokine, inhibits osteoclast differentiation, but the basis of this effect has been unclear. Osteoclastogenesis requires activation of RANK, which exerts its biologic effect via activation of NF-kappaB. NF-kappaB activation is manifested by nuclear translocation and binding to DNA, events secondary to phosphorylation and dissociation of IkappaBalpha. It is shown here that IL-4 reduces NF-kappaB nuclear translocation by inhibiting IkappaB phosphorylation, thus… CONTINUE READING