IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis.

@article{Young2000IL4II,
  title={IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis.},
  author={D A Young and Leslie D. Lowe and Susan S. Booth and Matthew J. Whitters and Lindsay B. Nicholson and Vijay K Kuchroo and Mary I. Collins},
  journal={Journal of immunology},
  year={2000},
  volume={164 7},
  pages={3563-72}
}
Experimental autoimmune encephalomyelitis (EAE) is induced in the SJL/J mouse by adoptive transfer of activated proteolipid protein peptide (PLP) 139-151-specific Th1 cells. T cells responding to altered peptide ligands (APL) of PLP, previously shown to induce Th2 differentiation and regulate disease in PLP-immunized mice, do not transfer EAE. However, the exact mechanism of disease regulation by APL-specific T cells has not been elucidated. In this report, we show that 1F1, a Th2 clone… CONTINUE READING

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