IL-37 inhibits IL-18-induced tubular epithelial cell expression of pro-inflammatory cytokines and renal ischemia-reperfusion injury.

@article{Yang2015IL37II,
  title={IL-37 inhibits IL-18-induced tubular epithelial cell expression of pro-inflammatory cytokines and renal ischemia-reperfusion injury.},
  author={Yunbo Yang and Zhu-Xu Zhang and Dameng Lian and Aaron Haig and Rabindra N. Bhattacharjee and Anthony M Jevnikar},
  journal={Kidney international},
  year={2015},
  volume={87 2},
  pages={
          396-408
        }
}
Cytokines and chemokines produced by tubular epithelial and infiltrating cells are critical to inflammation in renal ischemia-reperfusion injury. IL-37, a newly described IL-1 family member, inhibits IL-18-dependent pro-inflammatory cytokine production by its binding to IL-18 receptors and IL-18 binding protein. The potential role of IL-37 in renal ischemia-reperfusion injury is unknown. Here we found that exposure of tubular epithelial cells to exogenous IL-37 downregulated hypoxia and the IL… CONTINUE READING
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