IL-36γ is a Crucial Proximal Component of Protective Type 1-Mediated Lung Mucosal Immunity in Gram-Positive and Gram-Negative Bacterial Pneumonia

@inproceedings{Kovach2017IL36IA,
  title={IL-36γ is a Crucial Proximal Component of Protective Type 1-Mediated Lung Mucosal Immunity in Gram-Positive and Gram-Negative Bacterial Pneumonia},
  author={Melissa A. Kovach and Benjamin H. Singer and Giovanny Mart{\'i}nez-Col{\'o}n and Michael W. Newstead and Xianying Zeng and Peter Mancuso and Thomas A. Moore and Steven L. Kunkel and Marc Peters-Golden and Bethany B Moore and Theodore J Standiford},
  booktitle={Mucosal Immunology},
  year={2017}
}
Interleukin-36γ (IL-36γ) is a member of novel IL-1-like proinflammatory cytokine family that are highly expressed in epithelial tissues and several myeloid-derived cell types. Little is known about the role of the IL-36 family in mucosal immunity, including lung anti-bacterial responses. We used murine models of IL-36γ deficiency to assess the contribution of IL-36γ in the lung during experimental pneumonia. Induction of IL-36γ was observed in the lung in response to Streptococcus pneumoniae… CONTINUE READING