IL-36α Regulates Tubulointerstitial Inflammation in the Mouse Kidney

  title={IL-36α Regulates Tubulointerstitial Inflammation in the Mouse Kidney},
  author={Osamu Ichii and Junpei Kimura and Tadashi Okamura and Taro Horino and Teppei Nakamura and Hayato Sasaki and Yaser Hosny Ali Elewa and Yasuhiro Kon},
  booktitle={Front. Immunol.},
IL-36α, a member of the IL-1 family, is a crucial mediator of inflammatory responses. We previously found that IL-36α was overexpressed in injured distal tubules (DTs); however, its pathological function remains unclear. Herein, unilateral ureter obstruction (UUO) or folic acid (FA) injection was performed in mouse kidneys to assess the role of IL-36α in kidney injury. IL-36α mRNA and protein expression significantly increased in the kidneys within 24 h after UUO. IL-36α localized to dilated… CONTINUE READING
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