IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis

@inproceedings{Tu2017IL33inducedAA,
  title={IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis},
  author={Lei Tu and Jie Chen and Dandan Xu and Zhongming Xie and Bing Yu and Ying Y. Y. Tao and Guixiu Shi and Lihua Duan},
  booktitle={Oncotarget},
  year={2017}
}
Accumulated data have shown that alternatively activated macrophage exerts a modulatory role in many diseases, including colitis. Interleukin-33 (IL-33), a critical modulator in adaptive and innate immune, has been implicated in autoimmunity and inflammation. Previously, we have reported that IL-33 functions as a protective modulator in TNBS-induced colitis, which is closely related to a Th1-to-Th2/Treg switch. Here, we present novel evidence suggesting that IL-33 primes macrophage into… CONTINUE READING
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Anatomy of a discovery: m1 and m2 macrophages

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