IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex.

@article{Espinassous2009IL33EL,
  title={IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex.},
  author={Quentin Espinassous and Elvira Garcia-de-Paco and Ignacio Garcia-Verdugo and Monique Syngu{\'e}lakis and Sonja von Aulock and Jean-Michel Sallenave and Andrew N. J. McKenzie and Jean M. Kanellopoulos},
  journal={Journal of immunology},
  year={2009},
  volume={183 2},
  pages={
          1446-55
        }
}
Bacterial LPS triggers monocytes and macrophages to produce several inflammatory cytokines and mediators. However, once exposed to LPS, they become hyporesponsive to a subsequent endotoxin challenge. This phenomenon is defined as LPS desensitization or tolerance. Previous studies have identified some components of the biochemical pathways involved in negative modulation of LPS responses. In particular, it has been shown that the IL-1R-related protein ST2 could be implicated in LPS tolerance… CONTINUE READING
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