IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation

@inproceedings{Hardman2013IL33CR,
  title={IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation},
  author={Clare S Hardman and Veera Panova and Andrew N. J. McKenzie},
  booktitle={European journal of immunology},
  year={2013}
}
Interleukin-33 (IL-33) is an IL-1 family cytokine that signals via its receptor T1/ST2, and is a key regulator of inflammation, notably the type-2 response implicated in allergic asthma. Critical to our understanding of the role of IL-33 is the identification of the cellular sources of IL-33. Although progress has been made in this area, the development of a robust live cell reporter of expression would allow the localisation of IL-33 during ongoing immune responses. We have generated a… CONTINUE READING

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