IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis.

@article{Johnston2016IL33PI,
  title={IL-33 Precedes IL-5 in Regulating Eosinophil Commitment and Is Required for Eosinophil Homeostasis.},
  author={Laura K Johnston and Chia-Lin Hsu and Rebecca A Krier-Burris and Krishan D Chhiba and Karen B Chien and Andrew N. J. McKenzie and S Berdnikovs and P J Bryce},
  journal={Journal of immunology},
  year={2016},
  volume={197 9},
  pages={3445-3453}
}
Eosinophils are important in the pathogenesis of many diseases, including asthma, eosinophilic esophagitis, and eczema. Whereas IL-5 is crucial for supporting mature eosinophils (EoMs), the signals that support earlier eosinophil lineage events are less defined. The IL-33R, ST2, is expressed on several inflammatory cells, including eosinophils, and is best characterized for its role during the initiation of allergic responses in peripheral tissues. Recently, ST2 expression was described on… CONTINUE READING

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