IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells

@article{Yagami2010IL33MI,
  title={IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells},
  author={Akiko Yagami and Kanami Orihara and Hideaki Morita and Kyoko Futamura and Noriko Hashimoto and Kenji Matsumoto and Hirohisa Saito and Akio Matsuda},
  journal={The Journal of Immunology},
  year={2010},
  volume={185},
  pages={5743 - 5750}
}
IL-33 is a member of the IL-1 family and mediates its biological effects via the ST2 receptor, which is selectively expressed on Th2 cells and mast cells. Although polymorphic variation in ST2 is strongly associated with asthma, it is currently unclear whether IL-33 acts directly on lung tissue cells at sites of airway remodeling. Therefore, we aimed to identify the IL-33–responsive cells among primary human lung tissue cells. ST2 mRNA was expressed in both endothelial and epithelial cells but… 

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...

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