IL-33 (Interleukin 33)/sST2 (Soluble Suppression of Tumorigenicity 2) Axis in Hypertension and Heart Failure.

@article{Ghali2018IL333,
  title={IL-33 (Interleukin 33)/sST2 (Soluble Suppression of Tumorigenicity 2) Axis in Hypertension and Heart Failure.},
  author={Rana Ghali and Raffaele Altara and William E. Louch and Alessandro Cataliotti and Ziad Mallat and Abdullah Kaplan and Fouad A Zouein and George W Booz},
  journal={Hypertension},
  year={2018},
  volume={72 4},
  pages={
          818-828
        }
}
IL-33 (interleukin 33) is type of cytokine designated an alarmin, which is released under stress conditions or by cell death to induce protective measures in neighboring cells. It signals via the ST2 (suppression of tumorigenicity 2) receptor, which is also expressed as a truncated and soluble form that acts as a decoy receptor soluble ST2 (sST2). Substantial evidence supports the use of sST2 measurement as an indicator of cardiac stress and remodeling in hypertension, heart failure… CONTINUE READING
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