IL-33/ST2 involves the immunopathology of ocular toxoplasmosis in murine model

  title={IL-33/ST2 involves the immunopathology of ocular toxoplasmosis in murine model},
  author={Xinxin Tong and F. V. Lu},
  journal={Parasitology Research},
Ocular toxoplasmosis (OT) is the major cause of infective uveitis. Since the eye is a special organ protected by immune privilege, its immune response is different from general organs with Toxoplasma gondii infection. Here, we used Kunming outbred mice to establish OT by intravitreal injection of T. gondii RH strain tachyzoites, IL-33 expression in the eyes was localized by immunostaining, the levels of interleukin (IL)-33 and ST2 (IL-33 receptor) and T-helper (Th)1 and Th2-associated cytokines… CONTINUE READING
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