IL-3 receptor expression, regulation and function in cells of the vasculature.

Abstract

IL-3 is a haemopoietic growth factor which stimulates the production and functional activity of various blood cell types. Recent evidence suggests that the target cell population of IL-3 is not restricted to haemopoietic cells as previously thought, but vascular cells such as endothelial cells also express receptors for and respond to this cytokine. Interestingly, IL-3 was found to regulate endothelial responses related to inflammation, immunity and haemopoiesis. These findings, summarized in this review, offer new insight into the physiological function of IL-3 and may also be of clinical importance, as IL-3 is used in bone marrow reconstitution following cancer therapy.

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@article{Korpelainen1996IL3RE, title={IL-3 receptor expression, regulation and function in cells of the vasculature.}, author={E I Korpelainen and Jennifer R. Gamble and Mathew A. Vadas and Angel F Lopez}, journal={Immunology and cell biology}, year={1996}, volume={74 1}, pages={1-7} }