IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro

@article{Lantz2008IL3IR,
  title={IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro},
  author={Chris S. Lantz and Booki Min and Mindy Tsai and Devavani Chatterjea and Glenn Dranoff and Stephen J. Galli},
  journal={Laboratory Investigation},
  year={2008},
  volume={88},
  pages={1134-1142}
}
Basophils represent potential effector and immunoregulatory cells, as well as a potential source of IL-4, during the immune response elicited by infection with the nematode Nippostrongylus brasiliensis (N.b.), and in other settings. However, the factors which regulate the numbers of blood basophils in mice, or the ability of these cells to produce IL-4, are not fully understood. We found that infection of mice with the nematodes N.b. or Strongyloides venezuelensis (S.v.) induced substantial… CONTINUE READING