IL-3 induces down-regulation of CCR3 protein and mRNA in human eosinophils.

@article{Dulkys2001IL3ID,
  title={IL-3 induces down-regulation of CCR3 protein and mRNA in human eosinophils.},
  author={Yasmin Dulkys and Christof Kluthe and Thomas Buscherm{\"o}hle and Ines Barg and Sabine Knoess and Alexander Kapp and Amanda E. I. Proudfoot and J{\"o}rn Elsner},
  journal={Journal of immunology},
  year={2001},
  volume={167 6},
  pages={3443-53}
}
Cytokines and chemokines are responsible for the attraction and activation of eosinophils in allergic and inflammatory diseases. Whereas cytokines such as IL-3, IL-5, and GM-CSF activate eosinophils via heterodimeric receptors containing a distinct alpha-chain (binding domain) and a common beta-chain (signaling domain), chemokines such as eotaxin activate eosinophils via seven-transmembrane G(i) protein-coupled CCRs. Recent studies have demonstrated the importance of CCR3 on human eosinophils… CONTINUE READING