IL-3 induces differentiation of bone marrow precursor cells to osteoclast-like cells.

Abstract

IL-3, a cytokine with hematopoietic differentiating capability, induced murine bone marrow cells to differentiate into cells resembling osteoclasts. The cells resulting from treatment with IL-3 were multi-nucleated and demonstrated tartrate-resistant acid-phosphatase activity, as do resident osteoclasts found in bone. IL-3-induced osteoclast-like cell… (More)

Topics

  • Presentations referencing similar topics