IL-3-induced coexpression of histidine decarboxylase, IL-4 and IL-6 mRNA by murine basophil precursors.

@article{Schneider1999IL3inducedCO,
  title={IL-3-induced coexpression of histidine decarboxylase, IL-4 and IL-6 mRNA by murine basophil precursors.},
  author={Elke Schneider and Francios M Lemoine and Janine Breton-Gorius and François Machavoine and Anne Arnould and Elisabeth M. Cramer and Josette Guichard and Didier Michel},
  journal={Experimental hematology},
  year={1999},
  volume={27 6},
  pages={1010-8}
}
Murine low-density bone marrow cells sorted from the blast cell window on the basis of high rhodamine-123 retention (Rh-bright), are highly enriched in histamine-, IL-4-, and IL-6-producing cells. We established by in situ hybridization that up to 50% of this population (around 0.25% of the whole bone marrow) coexpressed the transcripts for these molecules upon stimulation with 1L-3. Rh-bright cells were also positive for mRNA encoding the alpha, beta, and gamma chains of the Fc(epsilon)RI… CONTINUE READING

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