IL-3 in dendritic cell development and function: a comparison with GM-CSF and IL-4.

@article{Lutz2004IL3ID,
  title={IL-3 in dendritic cell development and function: a comparison with GM-CSF and IL-4.},
  author={Manfred B Lutz},
  journal={Immunobiology},
  year={2004},
  volume={209 1-2},
  pages={79-87}
}
Dendritic cells (DC) develop in vivo from hematopoietic precursor cells. This process can be mimicked in vitro by growth factor stimulation. Among those factors granulocyte-macrophage colony-stimulating factor (GM-CSF) is the best known and most widely used for generation of rodent and human DC of the myeloid lineage. GM-CSF is often combined with interleukin-4 (IL-4) to suppress macrophage (Mph) outgrowth in cultures of human cells, but this does not apply to the mouse, and detailed analyses… CONTINUE READING

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