IL-28B Genetic Variants Determine the Extent of Monocyte-Induced Activation of NK Cells in Hepatitis C

@inproceedings{Krmer2016IL28BGV,
  title={IL-28B Genetic Variants Determine the Extent of Monocyte-Induced Activation of NK Cells in Hepatitis C},
  author={Benjamin Kr{\"a}mer and Claudia Finnemann and Beatriz Sastre and Philipp Lutz and Andreas Gl{\"a}ssner and Franziska Wolter and Felix Goeser and P Kokordelis and Dominik J Kaczmarek and Hans Dieter Nischalke and Christian P. Strassburg and Ulrich Spengler and Jacob Nattermann},
  booktitle={PloS one},
  year={2016}
}
BACKGROUND Immuno-genetic studies suggest a functional link between NK cells and λ-IFNs. We recently showed that NK cells are negative for the IFN-λ receptor IFN-λR1 and do not respond to IFN-λ, suggesting a rather indirect association between IL-28B genotype and NK cell activity. METHODS A total of 75 HCV(+) patients and 67 healthy controls were enrolled into this study. IL-28B (rs12979860) and IFNL-4 (rs368234815) genotypes were determined by rtPCR. Total PBMC, monocytes, and NK cells were… CONTINUE READING
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