IL-28 and IL-29: newcomers to the interferon family.

  title={IL-28 and IL-29: newcomers to the interferon family.},
  author={Gilles Uz{\'e} and Dani{\`e}le Monneron},
  volume={89 6-7},
IL-28 and IL-29 were recently described as members of a new cytokine family that shares with type I interferon (IFN) the same Jak/Stat signalling pathway driving expression of a common set of genes. Accordingly, they have been named IFN lambda. IFNs lambda exhibit several common features with type I IFNs: antiviral activity, antiproliferative activity and in vivo antitumour activity. Importantly, however, IFNs lambda bind to a distinct membrane receptor, composed of IFNLR1 and IL10R2. This… CONTINUE READING
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