IL 28 B polymorphisms and chronic hepatitis C

@inproceedings{Chevalieza2010IL2B,
  title={IL 28 B polymorphisms and chronic hepatitis C},
  author={S. Chevalieza and C. H{\'e}zodeb},
  year={2010}
}
  • S. Chevalieza, C. Hézodeb
  • Published 2010
Human genetic factors that influence HCV treatment responses have been identified by a recent landmark discovery. A SNP has been identified (rs12979860) located in chromosome 19,3 kb upstream of the IL28B gene that encodes IFN3, which was strongly associated with the sustained virological response (SVR) to pegIFN and ribavirin in more than 1000 patients with genotype 1 chronic hepatitis C. In patients of European ancestry, as well as in African-American and Hispanic patients, the CC genotype… CONTINUE READING

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