IL-28, IL-29 and their class II cytokine receptor IL-28R

  title={IL-28, IL-29 and their class II cytokine receptor IL-28R},
  author={Paul O. Sheppard and W. Kindsvogel and Wenfeng Xu and Katherine E. Henderson and Stacy M. Schlutsmeyer and Theodore E. Whitmore and Rolf E. Kuestner and Ursula Garrigues and Carl Birks and Jenny Roraback and Craig D. Ostrander and Dennis L Dong and Jin Eun Shin and Scott R. Presnell and Brian A Fox and Betty Haldeman and Emily Cooper and David W. Taft and Teresa Gilbert and F. J. Grant and Monica Tackett and William Krivan and Gary David Mcknight and Christopher H. Clegg and Don Foster and Kevin M. Klucher},
  journal={Nature Immunology},
Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor… 

IL-28A, IL-28B, and IL-29: promising cytokines with type I interferon-like properties.

Structure and function of interleukin-22 and other members of the interleukin-10 family

The recently published structures of IL-10 cytokine family members and their complexes with cognate transmembrane and soluble receptors as well as on interleukin physiology and physiopathology are reported on.

Structural features of the interleukin-10 family of cytokines.

  • A. Zdanov
  • Biology, Chemistry
    Current pharmaceutical design
  • 2004
This review summarizes all published three-dimensional structures of the cytokines representing theIL-10 family of homologs, including the IL-19 subfamily and their interaction with appropriate receptors.

IL-19 and IL-20: two novel cytokines with importance in inflammatory diseases

Results from animal experiments and massively increased expression of these mediators in human inflamed tissues support the assumption that they play an important role in the pathogenesis of a few inflammatory diseases.

Interleukin-10 and related cytokines and receptors.

These cytokines have significant roles in a variety of pathophysiological processes as well as in regulation of the immune system and further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a range of diseases.

Biology of interleukin-22

This chapter illuminates in detail the properties of IL-22 with respect to its gene, protein structure, cellular sources, receptors, target cells, biological effects, and, finally, its role in chronic inflammatory diseases, tumors, and infection.



A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist

It is demonstrated that IL-22RA2 binds specifically toIL-22 and neutralizes IL- 22-induced proliferation of BaF3 cells expressing IL-20Rα and IFN-γR1 on chromosome 6q23.3–24.2.

Interleukin (IL)-22, a Novel Human Cytokine That Signals through the Interferon Receptor-related Proteins CRF2–4 and IL-22R*

IL-22 does not inhibit the production of proinflammatory cytokines by monocytes in response to LPS nor does it impact IL-10 function on monocytes, but it has modest inhibitory effects on IL-4 production from Th2 T cells.

Identification of the Functional Interleukin-22 (IL-22) Receptor Complex

Sharing of the common IL-10R2 chain between the IL- 10 and IL-TIF receptor complexes is the first such case for receptor complexes with chains belonging to the class II cytokine receptor family, establishing a novel paradigm for IL-9-related ligands similar to the shared use of the gamma common chain by several cytokines.

Interleukin-10 and the interleukin-10 receptor.

Findings that have advanced the understanding of IL-10 and its receptor are highlighted, as well as its in vivo function in health and disease.

Identification and functional characterization of a second chain of the interleukin‐10 receptor complex

The CRFB4 chain, which is designated as the IL‐10R2 or IL‐ 10Rβ chain, serves as an accessory chain essential for the activeIL‐10 receptor complex and to initiate IL‐8‐induced signal transduction events.

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

The results indicate that IL-10 has important regulatory effects on immunological and inflammatory responses because of its capacity to downregulate class II MHC expression and to inhibit the production of proinflammatory cytokines by monocytes.

Interleukin-3 and interferon beta cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties.

It was concluded that monocytes cultured in the presence of IL-3 and IFN-beta differentiate into DCs with potent helper T-cell stimulatory capacity despite their low secretion of IL -12.

Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.

The cloning of the human IL-TIF cDNA is reported, which shares 79% amino acid identity with mouse IL- TIF and 25% identity withhuman IL-10, suggesting that this cytokine contributes to the inflammatory response in vivo.

IL-10 inhibits cytokine production by activated macrophages.

The potent action of IL-10 on the macrophage, particularly at the level of monokine production, supports an important role for this cytokine not only in the regulation of T cell responses but also in acute inflammatory responses.