IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

@inproceedings{Batten2010IL27SG,
  title={IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells},
  author={Marcel L Batten and Nandhini Ramamoorthi and Noelyn M. Kljavin and Cindy S Ma and Jennifer H. Cox and Hart S. Dengler and Dimitry M. Danilenko and Patrick Caplazi and Melanie Wong and David A. Fulcher and Matthew C. Cook and C Christopher King and Stuart G Tangye and Frederic J de Sauvage and Nico Ghilardi},
  booktitle={The Journal of experimental medicine},
  year={2010}
}
Maturation and selection of high-affinity B cell clones in the germinal center (GC) relies on support from T follicular helper (T(FH)) cells. T(FH) cells are characterized by their localization to the B cell follicle and their high expression of the costimulatory molecules ICOS and PD1 and the cytokine IL-21, which promotes immunoglobulin (Ig) class switching and production by B cells. We show that the heterodimeric cytokine IL-27 is critical for the function of T(FH) cells and for normal and… CONTINUE READING
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