IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation

@inproceedings{Dai2013IL27IH,
  title={IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation},
  author={Lue Dai and Kristy B. Lidie and Qian Chen and Joseph W. Adelsberger and Xin Zheng and Dawei Huang and Jun Yang and Richard A. Lempicki and Tauseef Rehman and Robin L. Dewar and Yanmei Wang and Ronald L. Hornung and Kelsey A. Canizales and Stephen J. Lockett and H. Clifford Lane and Tomozumi Imamichi},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
The susceptibility of macrophages to HIV-1 infection is modulated during monocyte differentiation. IL-27 is an anti-HIV cytokine that also modulates monocyte activation. In this study, we present new evidence that IL-27 promotes monocyte differentiation into macrophages that are nonpermissive for HIV-1 infection. Although IL-27 treatment does not affect expression of macrophage differentiation markers or macrophage biological functions, it confers HIV resistance by down-regulating spectrin… CONTINUE READING

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