IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities.

@article{Ho2009IL27DR,
  title={IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities.},
  author={Ming-Yi Ho and Sy Jye Christine Leu and Guanzhong Sun and Mitsunori Tao and Shuli Tang and Kuang-Hui Sun},
  journal={Journal of immunology},
  year={2009},
  volume={183 10},
  pages={
          6217-26
        }
}
Gene transfer of IL-27 to tumor cells has been proven to inhibit tumor growth in vivo by antiproliferation, antiangiogenesis, and stimulation of immunoprotection. To investigate the nonimmune mechanism of IL-27 that suppresses lung cancer growth, we have established a single-chain IL-27-transduced murine Lewis lung carcinoma (LLC-1) cell line (LLC-1/scIL-27) to evaluate its tumorigenic potential in vivo. Mice inoculated with LLC/scIL-27 displayed retardation of tumor growth. Production of IL-12… CONTINUE READING
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