IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1.

@article{Neufert2007IL27CT,
  title={IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1.},
  author={Clemens F. Neufert and Christoph Becker and Stefan Wirtz and Massimo Claudio Fantini and Benno Weigmann and Peter R. Galle and Markus F Neurath},
  journal={European journal of immunology},
  year={2007},
  volume={37 7},
  pages={1809-16}
}
IL-27 is an IL-12-related cytokine frequently present at sites of inflammation that can promote both anti- and pro-inflammatory immune responses. Here, we have analyzed the mechanisms how IL-27 may drive such divergent immune responses. While IL-27 suppressed the development of proinflammatory Th17 cells, a novel role for this cytokine in inhibiting the development of anti-inflammatory, inducible regulatory T cells (iTreg) was identified. In fact, IL-27 suppressed the development of adaptive… CONTINUE READING
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CD4CD25 cells to CD25Foxp3 regulatory T cells and for expansion of these cells

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