IL-26 Confers Proinflammatory Properties to Extracellular DNA

  title={IL-26 Confers Proinflammatory Properties to Extracellular DNA},
  author={Caroline Poli and Jean François Augusto and Jonathan Dauv{\'e} and Cl{\'e}ment Adam and Laurence Preisser and Vincent Larochette and Pascale Pignon and Ariel Savina and S. Blanchard and Jean François Subra and Alain Chevailler and Vincent Procaccio and Anne Crou{\'e} and Christophe Créminon and Alain Morel and Y Delneste and Helmut Fickenscher and Pascale Jeannin},
  journal={The Journal of Immunology},
  pages={3650 - 3661}
In physiological conditions, self-DNA released by dying cells is not detected by intracellular DNA sensors. In chronic inflammatory disorders, unabated inflammation has been associated with a break in innate immune tolerance to self-DNA. However, extracellular DNA has to complex with DNA-binding molecules to gain access to intracellular DNA sensors. IL-26 is a member of the IL-10 cytokine family, overexpressed in numerous chronic inflammatory diseases, in which biological activity remains… 

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