IL-25-responsive, lineage-negative KLRG1hi cells are multipotential “inflammatory” type 2 innate lymphoid cells

  title={IL-25-responsive, lineage-negative KLRG1hi cells are multipotential “inflammatory” type 2 innate lymphoid cells},
  author={Yuefeng Huang and Liying Guo and Jin Qiu and Xi Chen and Jane Hu-Li and Ulrich K Siebenlist and Peter R. Williamson and Joseph J. Urban and W. Jack Christie Edwin J. Crossman Peter J. Doherty A Paul},
  booktitle={Nature Immunology},
Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population responsive to interleukin 25 (IL-25) that complemented IL-33-responsive natural ILC2 (nILC2) cells. iILC2 cells developed into nILC2-like cells in vitro and in vivo and contributed to… CONTINUE READING
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