IL-25-responsive, lineage-negative KLRG1hi cells are multipotential “inflammatory” type 2 innate lymphoid cells

@inproceedings{Huang2015IL25responsiveLK,
  title={IL-25-responsive, lineage-negative KLRG1hi cells are multipotential “inflammatory” type 2 innate lymphoid cells},
  author={Yuefeng Huang and Liying Guo and Jin Qiu and Xi Chen and Jane Hu-Li and Ulrich K Siebenlist and Peter R. Williamson and Joseph J. Urban and W. Jack Christie Edwin J. Crossman Peter J. Doherty A Paul},
  booktitle={Nature Immunology},
  year={2015}
}
Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population responsive to interleukin 25 (IL-25) that complemented IL-33-responsive natural ILC2 (nILC2) cells. iILC2 cells developed into nILC2-like cells in vitro and in vivo and contributed to… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 6 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 78 extracted citations

Innate lymphoid cells in secondary lymphoid organs.

Immunological reviews • 2016
View 9 Excerpts
Highly Influenced

Innate lymphoid cells in intestinal immunity and inflammation

Cellular and Molecular Life Sciences • 2015
View 10 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 31 references

The transcription factor GATA 3 is critical for the development of all IL - 7 R α - expressing innate lymphoid cells

R. Yagi
Immunity • 2014

The transcription factor GATA3 is critical for the development of all IL-7Ralphaexpressing innate lymphoid cells

R Yagi
2014

A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis

M Salimi
J Exp Med • 2013

Innate lymphoid cells in immunity and disease.

Advances in experimental medicine and biology • 2013

Similar Papers

Loading similar papers…