IL-23 promotes osteoclast formation by up-regulation of receptor activator of NF-kappaB (RANK) expression in myeloid precursor cells.

@article{Chen2008IL23PO,
  title={IL-23 promotes osteoclast formation by up-regulation of receptor activator of NF-kappaB (RANK) expression in myeloid precursor cells.},
  author={Li Chen and Xiao-qing Wei and Bronwen A. J. Evans and Wenguo Jiang and Daniel Aeschlimann},
  journal={European journal of immunology},
  year={2008},
  volume={38 10},
  pages={2845-54}
}
Inflammation-mediated bone loss is a major feature of various bone diseases including rheumatoid arthritis, osteoarthritis and advanced periodontitis. Enhanced osteoclast development or activity at the inflammation site results in bone resorption. IL-23 is a heterodimeric cytokine belonging to the IL-6/IL-12 family that has been implicated in the pathogenesis of rheumatoid arthritis and demonstrated to play a role in osteoclastogenesis via stimulation of IL-17 production. In this study we… CONTINUE READING

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