IL-23 induces receptor activator of NF-kappaB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model.

@article{Ju2008IL23IR,
  title={IL-23 induces receptor activator of NF-kappaB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model.},
  author={Ji Hyeon Ju and Mi-La Cho and Young-Mee Moon and Hye Jwa Oh and Jin-Sil Park and Joo-Youn Jhun and So-Youn Min and Young-gyu Cho and Kyung-su Park and Chong-Hyeon Yoon and Jun-Ki Min and Sung-Hwan Park and Young Chul Sung and Ho Youn Kim},
  journal={Journal of immunology},
  year={2008},
  volume={181 2},
  pages={
          1507-18
        }
}
IL-23, a clinically novel cytokine, targets CD4(+) T cells. Recent IL-1Ra(-/-) mouse studies have demonstrated that IL-23 indirectly stimulates the differentiation of osteoclast precursors by enhancing IL-17 release from CD4(+) T cells. IL-17, in turn, stimulates osteoclastogenesis in osteoclast precursor cells. In this study, we found that IL-23 up-regulates receptor activator of NF-kappaB ligand expression by CD4(+) T cells, and thus contributes to osteoclastogenesis. This indirect pathway is… CONTINUE READING

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