IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

  title={IL-23 drives a pathogenic T cell population that induces autoimmune inflammation},
  author={Claire L. Langrish and Yi Chen and Wendy M. Blumenschein and Jeanine D. Mattson and Beth Basham and Jonathan Sedgwick and Terrill Mcclanahan and Robert A. Kastelein and Daniel J. Cua},
  journal={The Journal of Experimental Medicine},
  pages={233 - 240}
Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 cells that are essential for host defense and tumor suppression. In contrast, IL-23 does not promote the development of interferon-gamma-producing Th1 cells, but is one of the essential factors required for the expansion of a pathogenic CD4(+) T cell population, which is characterized by the production of IL-17, IL… CONTINUE READING
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