IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

@article{Langrish2005IL23DA,
  title={IL-23 drives a pathogenic T cell population that induces autoimmune inflammation},
  author={Claire L. Langrish and Yi Chen and Wendy M. Blumenschein and Jeanine D. Mattson and Beth Basham and Jonathan Sedgwick and Terrill Mcclanahan and Robert A. Kastelein and Daniel J. Cua},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={201},
  pages={233 - 240}
}
Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 cells that are essential for host defense and tumor suppression. In contrast, IL-23 does not promote the development of interferon-gamma-producing Th1 cells, but is one of the essential factors required for the expansion of a pathogenic CD4(+) T cell population, which is characterized by the production of IL-17, IL… CONTINUE READING
Highly Influential
This paper has highly influenced 146 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 1,668 extracted citations

Role of T Follicular Helper cells in Multiple Sclerosis.

Journal of nature and science • 2015
View 8 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Inducible costimulator is essential for collagen-induced arthritis.

The Journal of clinical investigation • 2003
View 1 Excerpt

Similar Papers

Loading similar papers…