IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

@article{Khader2007IL23AI,
  title={IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge},
  author={Shabaana A Khader and Guy K. Bell and John E Pearl and Jeffrey J. Fountain and Javier Rangel-Moreno and Garth E Cilley and Fang Shen and Sheri M. Eaton and Sarah L Gaffen and Susan L Swain and Richard M Locksley and Laura Haynes and Troy D. Randall and Andrea M Cooper},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={369-377}
}
Interferon-γ is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-γ response by CD4+ T cells in the lung during subsequent M. tuberculosis infection. Interleukin 23 (IL-23) was essential for the accelerated response, for early cessation of bacterial growth and for establishment of an IL-17-producing CD4+ T cell population in the lung. The recall response of the IL-17-producing CD4+ T cell population occurred concurrently with… CONTINUE READING
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