IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells.

@article{Belladonna2002IL23AI,
  title={IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells.},
  author={Maria Laura Belladonna and Jean-Christophe Renauld and Roberta Bianchi and Carmine Vacca and Francesca Fallarino and Ciriana Orabona and Maria Cristina Fioretti and Ursula Grohmann and Paolo Puccetti},
  journal={Journal of immunology},
  year={2002},
  volume={168 11},
  pages={5448-54}
}
IL-23 is a recently discovered heterodimeric cytokine that shares biological properties with proinflammatory cytokines. The biologically active heterodimer consists of p19 and the p40 subunit of IL-12. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12. We have constructed single-chain IL-23 and IL-12 fusion proteins (IL-23-Ig and IL-12-Ig) and have compared the two recombinant proteins for effects on murine dendritic cells (DC… CONTINUE READING

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