IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

  title={IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease},
  author={Alessandra Geremia and Carolina V. Arancibia-C{\'a}rcamo and Myles P.P. Fleming and Nigel Rust and Baljit Singh and Neil JMcC Mortensen and Simon P L Travis and Fiona Powrie},
  booktitle={The Journal of experimental medicine},
Results of experimental and genetic studies have highlighted the role of the IL-23/IL-17 axis in the pathogenesis of inflammatory bowel disease (IBD). IL-23-driven inflammation has been primarily linked to Th17 cells; however, we have recently identified a novel population of innate lymphoid cells (ILCs) in mice that produces IL-17, IL-22, and IFN-γ in response to IL-23 and mediates innate colitis. The relevance of ILC populations in human health and disease is currently poorly understood. In… CONTINUE READING
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