IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

  title={IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine},
  author={Samuel Huber and Nicola Gagliani and Lauren A Zenewicz and Francis Jessica Huber and Lidia Bosurgi and Bo Hu and Matija Hedl and Wei Zhang and William N. O’Connor and Andrew J. Murphy and David M. Valenzuela and George D. Yancopoulos and Carmen J Booth and Judy H Cho and Wenjun Ouyang and Clara Abraham and Richard A Flavell},
Chronic mucosal inflammation and tissue damage predisposes patients to the development of colorectal cancer. This association could be explained by the hypothesis that the same factors and pathways important for wound healing also promote tumorigenesis. A sensor of tissue damage should induce these factors to promote tissue repair and regulate their action to prevent development of cancer. Interleukin 22 (IL-22), a cytokine of the IL-10 superfamily, has an important role in colonic epithelial… CONTINUE READING
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