Corpus ID: 13713252

IL-22 promotes the migration and invasion of gastric cancer cells via IL-22R1/AKT/MMP-9 signaling.

@article{Ji2014IL22PT,
  title={IL-22 promotes the migration and invasion of gastric cancer cells via IL-22R1/AKT/MMP-9 signaling.},
  author={Yinghua Ji and Xiaoyu Yang and Jinsong Li and Zhihong Lu and Xiaorui Li and J. Yu and N. Li},
  journal={International journal of clinical and experimental pathology},
  year={2014},
  volume={7 7},
  pages={
          3694-703
        }
}
  • Yinghua Ji, Xiaoyu Yang, +4 authors N. Li
  • Published 2014
  • Biology, Medicine
  • International journal of clinical and experimental pathology
IL-22, one important inflammatory cytokine of the IL-10 family, exerts its functions via IL-22 receptor that is composed of IL-22R1 and IL-10R2 subunits. Although IL-22 expression is reported to be elevated in many cancers, and increased IL-22 expression correlates with tumor progression and poor prognosis, little is known about the role of IL-22 in gastric cancer. In our study, we found that IL-22 stimulation promoted the migration and invasion of SGC-7901 cells. Furthermore, IL-22 increased… Expand
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